Premular® (Ze 440) is a natural medicine clinically proven for the symptomatic relief of premenstrual syndrome (PMS); including symptoms of irritability, anger, headache, bloating and breast tenderness.1,2 Vitex agnus castus (Chaste tree) has a long history of use for hormonal conditions and menstrual complaints. Premular provides a clinically trialled and highly effective tablet extract of Vitex agnus castus, an evidence-based chaste tree product for the management of PMS.3-5